Proven Strategies to Combat Aging: A Scientific Approach

Above we looked at various things that cause the body to age which, in turn, can lead to impairment of bodily and cognitive functions as well as increased risk for various diseases. So what can we do to prevent this from happening?

Unfortunately, there’s no magic bullet. You will age. Your body will change. But there are ways of slowing down the process. In fact, some research suggest that some things can make you younger than what is considered your biological age. Below you will find what research has discovered so far.

Cellular Damage:

Antioxidants: Studies support the potential of antioxidants like Vitamin C, Vitamin E, and polyphenols in combating free radical damage linked to aging.

Increasing NAD+: Strategies to increase NAD+ levels, like supplementing with nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), have shown promise in promoting DNA repair and cellular health.

Anti-Glycation Agents: Research suggests that compounds like aminoguanidine and carnosine can inhibit the formation of AGEs and mitigate their damaging effects.

Autophagy: Encouraging cellular autophagy through methods like intermittent fasting and caloric restriction helps remove damaged cellular components, promoting cellular rejuvenation.

An overview of the role of NAD+ in cellular processes.

Collagen Production:

Collagen Supplements: Clinical trials have demonstrated that collagen supplements can enhance skin elasticity, hydration, and overall appearance.

Vitamin C: Topical and dietary Vitamin C boosts collagen synthesis and protects against UV-induced damage.

Retinoids: Prescription retinoids and over-the-counter retinol products stimulate collagen production and improve skin texture.

Hormone Production:

Bioidentical Hormone Replacement Therapy (BHRT): Studies suggest that BHRT may improve symptoms of hormone decline, such as hot flashes and reduced libido, although risks and benefits should be carefully considered.

Adaptogens: Herbs like ashwagandha and rhodiola have been researched for their potential to modulate hormone levels and reduce stress.

Neurotransmitter Balance:

Nootropics: Certain nootropic supplements, including Ginkgo biloba and Bacopa monnieri, have shown potential in enhancing cognitive function and neurotransmitter balance.

Exercise: Regular physical activity has been scientifically proven to enhance neurogenesis and maintain neurotransmitter balance, promoting brain health.

Sirtuins:

Resveratrol: Research supports the role of resveratrol, found in red wine and supplements, in activating sirtuins and extending lifespan in animal models.

Sirtuin Activators: Compounds like fisetin and quercetin are being studied for their potential to activate sirtuins and promote longevity.

Mitochondrial Function:

Coenzyme Q10 (CoQ10): Clinical studies have demonstrated that CoQ10 supplementation can enhance mitochondrial function and reduce fatigue.

PQQ: Research suggests that Pyrroloquinoline quinone (PQQ) may improve mitochondrial biogenesis and cellular energy production.

Exercise: Regular physical activity supports mitochondrial health by enhancing their efficiency and biogenesis.

Telomere Maintenance:

Telomerase Activators: Compounds like TA-65 and astragalus extracts are being investigated for their potential to activate telomerase and maintain telomere length.

Lifestyle Modifications: Research indicates that stress reduction, healthy diet, and regular exercise can positively impact telomere length and health.

Inflammation:

Anti-inflammatory Diet: Adopting a diet rich in anti-inflammatory foods like omega-3 fatty acids, turmeric, and green tea can reduce chronic inflammation.

Lifestyle Changes: Regular exercise, stress management, and sufficient sleep are proven strategies to mitigate inflammation.

Epigenetic Modulation:

Diet and Lifestyle: Evidence suggests that diet, exercise, and stress management can influence epigenetic markers and promote healthier gene expression.

Supplements: Compounds like sulforaphane and curcumin have shown potential in modulating epigenetic mechanisms linked to aging.

Protein Folding and Aggregation:

Chaperone Proteins: Research into molecular chaperones, like Hsp70, aims to understand their role in preventing protein misfolding and aggregation.

Autophagy: Encouraging autophagy through fasting and certain supplements, like spermidine, helps clear misfolded proteins.