Sirtuins, a class of proteins, are found in the human body in seven different forms and have a profound impact on wellness and longevity. Sirtuins are essential for mitochondria activity and energy generation, protein synthesis, DNA repair, metabolic health, DNA expression, healthy blood lipid and glucose levels, neuro-cognitive function, mood, circadian rhythm, and aging.

The botanicals in the Kimia Sirtuin Booster Formula each directly activate one or more of the seven sirtuins, and additionally the same pathways that activate NAD+ will also activate Sirtuins. This is due to the fact that increased NAD+ results in an increase in sirtuin activation.

Each Sirtuin has important physiological properties, some that are unique, but also some that are shared with other Sirtuins.



Is primarily localized to the nucleus to regulate DNA transcription in the cell’s protein factories, ribosomes. SIRT7 decreased expression has been correlated with age and premature physiological aging, making affected individuals appear to be older than the physiologic age showing that SIRT7 may have a role in aging and/or age-related conditions.



Sirtuins 1 through 7 have important overlapping synergies to orchestrate a healthy functioning body. These Sirt synergies govern everything from DNA repair, stem cells activity, immune response, inflamamtion, energy and metabolism, and so much more. The following are significant interating synergies of the various Sirtuins:
Sirt 1,3, and 7 work together for DNA repair and regulation

DNA repair Stem cells, Anti-inflammation, etc.
Sirt 1,3, and 7 oversee DNA repair and regulation.
Sirts 1, 3,4 and 5 work together to control cell respiration, i.e., energy production, mitochondria formation and activity. Sirts 2 and 5 regulate immune response.
Sirts 1 and 6 coordinate endocrine hormone functions and insulin, IGF-1 activities.
Sirts 2, 3, 6, and 7 control aspects of the rate of aging process.
Sirts 1, 4, 5, 6, and 7 regulate metabolism of fats, cholesterol, glucose, and protein synthesis.
Sirts 3, 4, and 5 are important for certain vital organs including the heart, brain, liver, and kidneys.
Sirts 2, 5 and 6 regulate stem cell activity.
Sirts 1, 2 and 5 regulate autophagy and apoptosis, processes involved in removing damaged cells and recycling older or damaged cell parts, respectively.
Sirts 2, 3, and 6 helps with adapting to cell and organism stress
Sirts 2 and 6 regulate oxidative stress response and antioxidant activity.



Chen Pi, Pysllium seed




Sirtuin 7

Found in