Anti-Aging Synergy Set
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Powerful benefits
NAD+ Boost & Sirtuins Boost Anti-Aging Synergy Set
Anti-aging Elixir
Sirtuins are a group of protein enzymes produced in the body that act as protectors for our cells by responding to damage and repairing it. They restore a more youthful metabolism by improving insulin sensitivity, lowering blood sugar, increasing energy output from mitochondria, and helping stabilize telomeres and stem cells. Kimia Sirtuin Boost is specially designed to help boost sirtuin levels in the body.
Enhance Sirtuins
Sirtuin activity naturally decreases with age and is associated with a decline in cardiovascular function. Boosting sirtuin levels and activity helps improve cardiovascular health, supports protein synthesis, and promotes tissue renewal through stem cells. Sirtuins help remove and recycle old, decaying parts of our cells into new or repaired cells.
Healthy Gene Expression
Sirtuins play a vital role in maintaining gene integrity, helping sustain healthy chromosomes, and repairing genes that have become fragmented. They promote the expression of gene transcription factors for healthy lipid metabolism, antioxidant activity, inflammation response, improved energy metabolism, and the activation of longevity genes.
Healthy Inflammation Response
Sirtuins have anti-inflammatory properties due to their regulatory effects on immune system receptors and gene transcription factors. Healthy sirtuin levels can help regulate the activation of a healthy inflammation response to infectious microbes and host proteins, helping restore metabolic balance during stress.
Skin Health & Beauty
There are 7 main Sirtuins in the body. Sirtuins 3 and 6 support collagen protein synthesis needed for skin and collagen renewal. In skin cells, sirtuins help maintain skin integrity, boosting DNA repair, a major factor in aging. Sirtuin 4 helps skin maintain a balance between producing sufficient ATP for healthy, glowing skin, while reducing oxidative damage.
DNA Health
As a part of our normal life cycle, our DNA molecules may become damaged. Sirtuins are responsible for repairing, restoring and protecting DNA in the body. They help repair broken ends and activate DNA repair factors in the cell. Kimia Sirtuin Boost helps replenish sirtuins with botanicals that increase levels of NAD+ and decrease levels of sirtuin inhibiting CD38.
NAD+ Benefits
NAD+ is essential for the production of Sirtuins that are the key to maintaining good health, especially in our later years. NAD+ also helps maintain healthy mitochondria function in the cell, reduces aging of stem cells that can differentiate into new tissue, and helps maintain a healthy heart and blood vessels.
Energy Metabolism
Energy metabolism is vital for powering all of our fundamental physiological functions, including muscle contraction, fat metabolism, thinking processes, cellular defenses, cell division, and reproduction. NAD+ helps maintain healthy mitochondria, which are the energy producers of the cell.
Support CD38 Inhibition
CD38 is an enzyme protein made in your body that is found on the surface of immune cells. It is known to lower NAD+ levels, so inhibition of CD38 can effectively boost NAD+ levels. There are many natural CD38 inhibitors in plant-based foods such as the flavonoids apigenin, luteolin, and quercetin found in parsley, apples, and artichoke.
Cognitive Support
Adequate levels of NAD+ are important as we age for maintaining the health of mitochondria, the energy producers of the cell. NAD+ is a key enzyme in the production of energy molecule ATP, which has been shown to be a vital part of our normal brain cellular function.
Immune Support
NAD+ is a natural component of a healthy immune response in the body. It is a critical agent in the metabolism and function of T cells, natural killer cells and macrophages, which are an important part of our natural defenses.
Kimia NAD+ (Morning):
Disclaimer:
Please note that the capsule size may differ slightly from the product images due to specialized filling techniques. Variations in capsule density may occur amongst NAD+ and Sirtuins, but rest assured, the potency and effectiveness of the formula remain consistent.
What does "Pathways activated" mean?
A single herb can contain over 500 active compounds, each capable of activating various biological pathways—specific sequences of actions within cells that address imbalances in the body. At Kimia, advanced formulation techniques assign roles to each herb, creating a synergistic blend that achieves multi-pathway activation more effectively than many other herbal products.
Pathways activated
NAMPT
NAD+ is mainly synthesized by the Salvage Pathway in the human body which goes through two vital enzyme steps NAMPT and NMNT for its formation. NAMPT is the most important as the rate limiting enzyme....
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AMPK
Activation of AMPK increases the NAD+/NADH ratio. An increase in NAD+ after exercise supports the idea that changes in NAD+ levels are based on AMPK increasing SIRT1 activity. AMPK enhances SIRT1 activity through increasing cellular...
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CD-38 Inhibition (NAD+)
A compound produced in the body called CD38 provides a counteracting balance to NAD+ and Sirtuins, and can be produced to problematic excess as a result of aging, viral infection, or chronic inflammation. Inhibiting CD38...
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Sirtuin-1 (NAD+)
SIRT1 boosts NAD+ by acting on NAMPT found inside the cells (iNAMPT) facilitating it’s secretion from fat cells (adipocytes) into the extra-cellular space outside of cells where it becomes known as eNAMPT. SIRT1 enhances eNAMPT...
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DNA damage blockage
Oxidative stress is a cause of NAD+ depletion, and aging increases both oxidative stress and NAD+ depletion as well as the loss of SIRT1 activity. Strong positive correlations were also observed between lipid peroxidation and...
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Lower inflammatory response support
Since chronic and excessive inflammation depletes NAD+ through increased CD38 levels, another way of boosting NAD+ is to support a lower inflammation response to reduce CD38+ levels by using inflammation-support botanicals. (Poljšak, 2023).
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NAD de novo Synthesis
Besides the two main NAD+ synthesis pathways the body uses to form NAD+ from its precursors (Salvage pathway from niacinamide vit. B3) and the Preiss-Handler pathway (from dietary niacin), the third pathway, known as the...
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PARP Inhibition
NAD+ is depleted when extensive DNA damage causes activation of a DNA repair enzyme known as PARP (poly-ADP-ribosyl Polymerase) found in the cell nucleus. Increased PARP activity and DNA damage are elevated with aging. PARP...
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Sirtuin 3
Is designated as a mitochondrial sirtuin since its active form is localized in the mitochondria and translocates there in response to stress (e.g., DNA damage), and is involved in cardiovascular, kidney, and neurological health. SIRT3...
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Sirtuin 2
Its functions in the nervous system, cell differentiation, aging, normal infection response, and autophagy (cell recycles damaged parts).
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Sirtuin 4
Activates vitally important function for protein synthesis and mitochondria function. Relatively high levels found in the heart, muscle, brain, liver and kidney with an important role in regulating protein function.
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Sirtuin 5
Its functions for respiration, processing proteins and control of fat oxidation. It is highly expressed in the tissues of the brain, heart, liver, and immune stem cells. SIRT5 has roles detoxification, and mediation of the...
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Sirtuin 6
has critical functions in cellular processes such as gene expression, glucose homeostasis, DNA repair, and may be involved in regulating the aging process. Needed for insulin-like growth factor (IGF-1) levels, a protein related to growth...
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Sirtuin 7
Is primarily localized to the nucleus to regulate DNA transcription in the cell’s protein factories, ribosomes. SIRT7 decreased expression has been correlated with age and premature physiological aging, making affected individuals appear to be older...
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NAD+ Boosting
NAD+ is essential for the activity of sirtuins, as it acts as a coenzyme that enables sirtuins to carry out their functions in the cell. The interaction between NAD+ and sirtuins is part of a...
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Herbal pathways that increase Sirtuins overall
AMPK, PARP inhibition, NAMPT, CD38 inhibition
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