Sirtuin-1 (nad+)
NAD+ MULTI-PATHWAYS SYNTHESIS
Having optimum NAD+ levels is vital for healthy energy, fat and glucose metabolism, insulin regulation, DNA repair, inflammation response, and a host of other health effects.
NAD+ levels and activity are elevated by four main pathways, and two additional secondary pathways from the botanicals in the Kimia NAD+ Booster. The following is a description of each NAD+ boosting pathway and which of the following herbs in the formula are activated by that pathway.
HOW IT WORKS
SIRT1 causes NAMPT to be secreted from fat cells (adipocytes) into the extra-cellular fluid which is acts as a main NAD+ synthesis enzyme
NAD+ BOOST PATHWAY MECHANISM
SIRT1 boosts NAD+ by acting on NAMPT found inside the cells (iNAMPT) facilitating it’s secretion from fat cells (adipocytes) into the extra-cellular space outside of cells where it becomes known as eNAMPT. SIRT1 enhances eNAMPT activity and secretion. Increases in circulating eNAMPT have been shown to increase NAD+/SIRT1 and physical activity accordingly (Yoon, 2015). Sirt3 is also a booster of NAD+.
NAD+ BOOST PATHWAY DEFINITION
Sirtuins remove certain molecules (acetyl group) from DNA that act as off/on switches to regulate virtually every physiological process.
