NAD+ MULTI-PATHWAYS SYNTHESIS

Having optimum NAD+ levels is vital for healthy energy, fat and glucose metabolism, insulin regulation, DNA repair, inflammation response, and a host of other health effects. NAD+ levels and activity are elevated by four main pathways, and two additional secondary pathways from the botanicals in the Kimia NAD+ Booster. The following is a description of each NAD+ boosting pathway and which of the following herbs in the formula are activated by that pathway.

HOW IT WORKS

PARP uses up very large amounts of NAD+, but by its inhibition preserves it.

PATHWAY SYNERGIES

 NAD+ is depleted when extensive DNA damage causes activation of a DNA repair enzyme known as PARP (poly-ADP-ribosyl Polymerase) found in the cell nucleus. Increased PARP activity and DNA damage are elevated with aging. PARP requires NAD+ for its function using it up. Proanthocyandin compounds (PAC’s) have been shown to inhibit excessive PARP activity, possibly by DNA protective activity. Some PARP is needed for essential DNA repair but when excessive activated through higher levels of DNA damage this results in over-expression of PARP and a severe depletion of NAD+.

 NAD+ BOOST PATHWAY DEFINITION

PARP is a DNA repair enzyme that when over-expressed can cause a cell to commit apoptosis or self-triggered death. It also depletes NAD+ levels if over-expressed.